Protease Activators


Protein StructureMadera has a number of small molecule, highly potent direct activators of the mitochondrial protease, ClpP known as “TR Compounds.” Professor Lee Graves of UNC and Madera identified the first highly potent small molecule activators of the mitochondrial caseinolytic protease P (ClpP). ClpP, part of the ClpXP complex, is located in the mitochondrial matrix and is responsible for protein quality control.

Madera’s collaborators at the NIH/NCI and UNC have also characterized the effects of the TR Compounds on cancer stem cell function.Madera’s small molecules are designed to be specific to ClpP, have high oral bioavailability, excellent cell permeability, and meet rigorous large pharma-like safety standards. Madera, UNC and others have described one of Madera’s lead agents, TR-107 in a recent publication. A portfolio of families of patents and patent applications protects Madera’s discoveries.

Protein structure images provided by Dr. Houry