Madera is the leader in the design and development of specific, highly potent direct activators of mitochondrial proteases. Professor Lee Graves of UNC and Madera identified the first highly potent small-molecule activators of the mitochondrial caseinolytic protease P (ClpP). ClpP is located in the mitochondrial matrix and is responsible for protein quality control. Madera’s small molecules are designed to be specific to ClpP, have high oral bioavailability, excellent cell permeability, and meet rigorous large pharma-like safety standards. A portfolio of families of patents and patent applications protects Madera’s discoveries.
Protein structure images provided by Dr. Houry